Study links liver cancer to epigenetic changes
BROBROK News · Based on reporting by DiarioBitcoin ·
A mouse study suggests that YAP1-TEAD activation may promote hepatocellular carcinoma even when no canonical driver mutations are detected. Researchers also found similar signals in hepatocytes from patients with Fontan-associated liver disease.
Key points
- Whole-exome sequencing found no canonical driver mutations in the tumors from the model.
- Methylation analysis showed widespread DNA demethylation in the liver cancers.
- Lowering Tet1 activity reduced tumor formation in mice.
- The study found YAP1-TEAD-TET1 signatures in hepatocytes from patients with FALD.
Why it matters
The findings support the idea that some cancers can emerge through epigenetic changes, not just well-known genetic mutations. That could help explain tumors where standard tests do not find expected driver alterations.
Original headline: “Cáncer de hígado: un estudio apunta a cambios epigenéticos sin mutaciones impulsoras detectables”
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